Wexford reached Madras on 4 August, and Penang on 7 September; she arrived at Whampoa Anchorage on 23 October.

As they were passing through the Straits of Malacca, they encountered a French squadron under Counter-Admiral Charles-Alexandre Léon Durand Linois, who hoped to seize as many of them as he could.

[5] EIC voyage #2 (1805-1806): Captain William Stanley Clarke sailed from Portsmouth on 1 February 1805, bound for Bombay and China.

Early in February Wexford ran foul of Pitt damaging her and forcing her to put back into Portsmouth to effect repairs.

[6] On 5 February the incompetence of her pilot caused Earl of Abergavenny to strike on the Shambles off the Isle of Portland; she then sank in Weymouth Bay with the loss of 263 lives.

[2] At Bombay the EIC fitted out Wexford and Earl Camden to cruise in the Indian Ocean for the "protection of trade".

[2] EIC voyage #3 (1807-1809): Captain Charles Barnard acquired a letter of marque on 22 May 1807, and sailed from Portsmouth on 22 June, bound for Madras, Bombay, and Persia.

[2] EIC voyage #4 (1809-1811): Captain William Stanley Clarke acquired a letter of mark on 7 December 1809.

Homeward bound, she crossed the Second Bar on 12 February 1811, reached St Helena on 29 May, and arrived at the Down on 8 August.

[2] EIC voyage #5 (1812-1813): Captain Charles Barnard sailed from Portsmouth on 25 March 1812, bound for China.

Homeward bound , she crossed the Second Bar on 3 January 1813, reached St Helena on 27 March, and arrived at the Downs on 5 June.

Homeward bound, she crossed the Second Bar on 22 January 1815, reached St Helena on 19 April, and arrived at the Downs on 23 June.

Homeward bound, she crossed the Second Bar on 29 March, reached St Helena on 6 July, and arrived at the Downs on 26 August.