[5] Wheeling Creek rises in Flushing Township just east of the community of Flushing, and flows generally east through Union, Wheeling, Richland, Colerain, and Pease Townships, past the communities of Lafferty, Bannock, Fairpoint, Maynard, Barton, Blaine, Lansing, and Brookside, to Bridgeport, where it flows into the Ohio River from the west, just upstream of the mouth of West Virginia's Wheeling Creek on the opposite bank.

The National Road (U.S. Route 40) parallels the stream between Bridgeport and Blaine.

[5] At its mouth, the estimated mean annual flow volume of Wheeling Creek is 123.46 cubic feet per second (3.496 m3/s).

[4] The United States Geological Survey operates a stream gauge on the creek downstream of Blaine, 4.8 miles (7.7 km) upstream of the creek's mouth.

[6] According to the Geographic Names Information System, Wheeling Creek has also been known historically as:[1]