Wiesbaden-Schierstein station is a railway station in the borough of Schierstein in the Hessian state capital of Wiesbaden on the East Rhine Railway from Wiesbaden to Cologne.

It is classified by Deutsche Bahn as a category 6 station.

Schierstein lies in the area served by the Rhein-Main-Verkehrsverbund (Rhine-Main Transport Association, RMV).

It is used by StadtExpress trains operated by VIAS, and buses.

Regionalbahn services operate at hourly intervals on the Frankfurt Hauptbahnhof–Koblenz Hauptbahnhof route.