Esthero was dropped from Work in late 1999 due to poor sales of her first album Breath from Another, and the label's absorption into Epic Records.

Vibe described the album's style as "an alternately futuristic and vintage soundscape of reggae, jazz, hip hop, and electronica.

"[4] AllMusic's Johnny Loftus commented that the album falls "in a drifty place between modernized trip-hop (and) mild R&B.

"[5] Regarding the album's stylistic eclecticism, Esthero stated in an interview with The Washington Post that her "taste is so vast it ends up like a premixed iPod shuffle.

Johnny Loftus of Allmusic felt that Wikked Lil' Grrrls is a "personal statement, if not a labor of love", however considers that the album "occasionally gets lost between songwriting, thematics, and stylistic flow".

[11] In extremely negative review from Splendid magazine, Mike Meginnis said: "A towering monument to Esthero's overpowering sense of self satisfaction, this mess overstays its welcome and abuses whatever attention you're willing to spend on it.

[13] The title track appeared on the soundtracks to Miss Congeniality 2 and John Tucker Must Die, a season five episode of Smallville, and was used in an early promotion for the TV shows Desperate Housewives, and Las Vegas.

[15] "Everyday Is a Holiday (With You)" was featured in the 2005 film Monster-in-Law, and was used in a season two episode of the ABC medical drama Grey's Anatomy.