His father died at the Battle of Ancrum Moor in 1545, leaving William as the heir to his grandfather's peerage.

[2] Like his father and grandfather before him, Eure spent much of his life in the borderlands of Scotland and England.

Sometime before 1557, he was appointed, jointly with Thomas Wharton, Captain of Berwick Castle, and he served under the Earl of Sussex in his 1570 invasion of Scotland.

[4] They had five sons and six daughters,[3] including:[5] Margaret Eure predeceased her husband, dying in 1591, and was buried on 15 September 1591 at Ingleby, Lincolnshire.

[4] Lord Eure died on 12 September 1594 and was buried at Ingleby the next day.