Williston is a town in Barnwell County, South Carolina, United States.

This section of the train route is now part of the South Carolina Heritage Corridor.

The Ashley-Willis House was listed on the National Register of Historic Places in 2004.

[4] As of the 2020 United States census, there were 2,877 people, 1,296 households, and 607 families residing in the town.

27.8% of all households were made up of individuals, and 12.3% had someone living alone who was 65 years of age or older.

A private school in Blackville, Jefferson Davis Academy, also serves a portion of the town's population.