He was optioned back to Durham three days later to make room for Joey Wendle, who was returning from the paternity list.

[14] On July 12, Adames was sent back down to Durham in order to receive more consistent playing time, due to the jam at middle infield between Wendle, Adeiny Hechavarria, Daniel Robertson, and Matt Duffy.

[14] On August 7, Adames hit a walk off solo home run against Miguel Castro of the Baltimore Orioles.

[24] In the American League Division Series, Adames posted a .385/.500/.983 slash line, hitting two home runs and a double as the Rays lost to the pennant winning Houston Astros in five games.

Adames batted .143 with one RBI in the World Series, which the Rays lost to the Los Angeles Dodgers in six games.

On May 21, 2021, the Rays traded Adames alongside Trevor Richards to the Milwaukee Brewers in exchange for relievers Drew Rasmussen and J. P.

[30] On January 13, 2023, Adames agreed to a one-year, $8.7 million contract with the Brewers, avoiding salary arbitration.

[31] On September 2, 2024, Adames tied the major league shortstop record for hitting a home run in five consecutive games.

Adames shares the record with Eddie Miller (1940), Alex Rodriguez (1999 and 2003), Corey Seager (2022), Trea Turner (2023) and Tyler Fitzgerald (2024).

[32][33] Adames ended the year with a 4.7 wins above replacement, making him one of the 20 most valuable players in the league by that metric in the 2024 season.

He started all but one of the Brewers' regular season games, had a slash line of .251/.331/.462, and hit 18% better than the average major league player (OPS+).

[34][35][36] The contract included a $22 million signing bonus, a full no-trade clause, and no deferred money.