In contrast to the usual storylines focused on Gregory House, this episode is centered on James Wilson and a day in his life.
Gregory House wakes James Wilson from sleep at 6:30 a.m. by playing his guitar and singing "Faith" by George Michael.
During the treatment process, irrespective of House's warning, Wilson decides to employ a double dose of chemotherapy, which cures the cancer but leads to severe liver damage.
House informs Wilson of a recently admitted motorcycle accident victim who might be a potential donor, but his sister, an Asian woman who appears to be a member of Mahikari, is unwilling to allow the organ donation because she does not want to violate his remains before burial.
After visiting the sister at home and unsuccessfully trying to convince her, Wilson learns that it is too late anyway as the accident victim’s liver has already degraded beyond usefulness.
While Wilson feels that to do so would violate his professional ethics, he considers complying due to a sense of guilt over prescribing the double dose of chemotherapy that destroyed Tucker’s liver.
After seeing how Tucker had reunited with his estranged family in light of his dire situation and wishing to extend this time for him, Wilson finally relents to his friend's plea and plans to go ahead with the operation to donate a portion of his liver.
Now that he is going to live, Tucker reveals he is summarily casting his family aside again to pursue another new love interest, one even younger (almost the same age as his own daughter).