It runs in a north–south in northwest Wisconsin from Marengo to Ashland.

After over 3 miles (4.8 km) of traveling westward, it then turns northward north of Sanborn.

After crossing the river, it then intersects WIS 118.

Continuing north, it then encounters the John F. Kennedy Memorial Airport, then enters the city of Ashland, and then intersects WIS 137 before it intersects US 2/WIS 13.

[2] The entire route is in Ashland County.