It runs in north–south in south central Wisconsin from near Dodgeville to near Hill Point.

It joins with WIS 133 immediately before they cross the Wisconsin River.

After crossing the river, the highways enter Lone Rock.

WIS 130 then turns north away from US 14 and meanders northward, passing through Bear Valley and Sandusky.

In 1948, WIS 130 was extended northward via CTH-J, CTH-N, and CTH-G.[5][6] In 1949, part of the WIS 130 extension was moved northwestward away from CTH-N and CTH-G.[6][7]