It was directed by Yoshimitsu Ōhashi, with Yasuko Kobayashi handling series scripts, Makoto Uno designing the characters and Masa Takumi composing the music.

Masane becomes entangled in a power struggle between a large corporation and a government agency, and discovers that a mysterious bracelet on her right wrist is the legendary Witchblade.

Produced by Gonzo and directed by Yoshimitsu Ohashi, Witchblade was broadcast from April 6 to September 21, 2006, on CBC and TBS.

[15] In the United Kingdom, the series was licensed by MVM Films, with six DVD sets released from February 4 to December 15, 2008.

[21] Crunchyroll added the series to their catalog in February 2018, streaming it in its original Japanese language with English subtitles.