Woods Hole is a strait in Massachusetts separating the Elizabeth Islands from the village of Woods Hole on the mainland of Cape Cod.

It is one of four straits allowing maritime passage between Buzzards Bay and Vineyard Sound.

The eastern (Vineyard Sound) side of the channel also splits into a southern branch, known as Broadway, which flows closer to Nonamesset Island.

Several similar straits in the area are also referred to as "holes", but this term is not used in the U.S. outside of the Cape and Islands.

The source of "Woods" is also hazy but is believed to have been derived from the possessive form of the name of a Wampanoag living in the area during English colonization of Cape Cod in the 17th century.