Under Rutten, Brama found himself out of the first team, with Orlando Engelaar, Karim El Ahmadi and Otman Bakkal preferred in the starting eleven at midfield instead and played in the reserve side.

[9] He made his European debut on 15 July 2006 in a UEFA Intertoto Cup match, playing 90 minutes, in a 1–0 loss against Kalmar; ultimately winning 3–1 in the second leg.

[18] Brama then made his UEFA Champions League debut in the play–offs round on 13 August 2008, starting the whole game, in a 2–0 loss against Arsenal; and also played again in the second leg, which saw them lose 4–0[19] He then started in every match since the opening game of the season against Roda JC, until he suffered a thigh injury in early November.

[20] After returning from injury, Brama regained his first team place and then set up a goal for Blaise Nkufo, who later scored a hat–trick, in a 6–0 win over Heracles Almelo on 22 November 2008.

[30] After being suspended once again,[31] Brama continued to remain in the first team and helped the club win the league for the first time after beating NAC Breda 2–0 in the last game of the season.

He also finished third place behind Douglas and Bryan Ruiz for the club's player of the year voted by supporters.

[39] Shortly after signing a new contract, Brama scored his first goal of the season, in a 2–1 win over Feyenoord on 30 January 2011.

[46] Brama started the season well when he helped the club once again beat Ajax 2–1 in the Johan Cruyff Shield.

[48] Five days later, on 20 October 2011, Brama scored again in a UEFA Europa League match, in a 4–1 win over OB.

[49] He then set up two goals for Peter Wisgerhof and Ola John, in a 4–0 thrashing victory over De Graafschap on 6 November 2011.

[50] Throughout the January transfer window, Brama continued to be linked with a move away, with SV Werder Bremen interested but eventually stayed at the club.

[52] The following month, Brama was given a captaincy for the first time on 15 March 2012, in a 4–1 loss against Schalke 04 in second leg of the last 16 that saw them eliminated in the UEFA Europa League.

[58] After suffering ankle injury in late–August,[59] Brama continued to regain his first team place throughout the season, as well as, captain.

[68] In a follow-up match, Brama made his first appearance of the season on 30 March 2014, coming on as a second–half substitute, in a 3–0 loss to Ajax.

With his contract expiring at the end of the 2013–14 season, Brama said about his future: " We had four weeks of vacation and I thought that was long enough.

[77] Brama ended his stay at FC Twente for over 10 years when he joined PEC Zwolle on 16 October 2014, signing a one–year contract.

[81] After being sidelined with injuries,[82] Brama played against his former club, Twente, coming on as a second–half substitute, in a 2–1 loss on 23 November 2014.

[88] Brama also missed out over in the Final of the KNVB Cup, where he was placed on the substitute bench, as PEC Zwolle lose 2–0 to Groningen.

[90] Although he was linked a move back to Twente, Brama ultimately signed a two–year contract at PEC Zwolle at the end of August.

[95] Despite being sidelined from the first team on three occasions,[96] Brama finished his full season at PEC Zwolle, making 28 appearances and scoring two times in all competitions.

[98] Despite suffering from a thigh injury,[99] Brama continued to be in the first team for the side and made a total of 17 appearances and scoring once in the first half of the season.

[103] Brama made his FC Utrecht debut, starting the whole game, in a 2–1 win over Sparta Rotterdam on 14 January 2017.

[105] Brama also helped the side qualify for the UEFA Europa League after beating SC Heerenveen and FC Utrecht.

On 29 July 2017, Brama signed a two-year contract with Central Coast Mariners, moving abroad for the first time, joining his compatriot Tom Hiariej.

[109] Upon joining the club, Brama said of the move: " I have been playing in the Netherlands for a long time so I was immediately enthusiastic when I was approached by Central Coast Mariners.

For me it's a big step, I spoke with Tom Hiariej and he was very positive about this club, it's nice to have another Dutchman there, which makes the beginning easier.

[113] Since making his Central Coast Mariners debut, Brama quickly established himself in the first team and played every match until his controversial sending off in a second–half for scraping Roly Bonevacia's calf, in a 2–0 loss against Western Sydney Wanderers on 16 November 2017.

[121][122] His last professional appearance came on June 11, 2023, during a play-off match for European football against Sparta Rotterdam which ended in a 1–0 victory.

[131] Four months later, Brama made another Netherlands B appearance on 27 March 2009, started and played 45 minutes before being substituted, in a 4–0 win over Germany U21.

[134] The day after Twente won the league for the first time, Brama, along with teammate Sander Boschker, were included in the provisional squad of 30 players for the 2010 FIFA World Cup.