Wyoming Highway 374 begins its western end at exit 61 of Interstate 80, southwest of Granger.

WYO 374 travels along the north side of I-80, acting as a frontage road, for just under 5 miles until it reaches U.S. Route 30 where it temporarily ends.

[3][4] Now Highway 374 travels eastward toward Green River on the south side of the interstate.

As WYO 374 enters James Town, a census-designated place (CDP) west of Green River, Covered Wagon Road (CR 59) is intersected which provides access to exit 85 of I-80/US 30 and travels north to the Rolling Green Country Club.

[3] Wyoming Highway 374 is the original alignment of U.S. Route 30 from near Granger to Green River.