Wyoming Highway 450 (WYO 450) is a 66.22-mile-long (106.57 km) east-west Wyoming State Road in Campbell and Weston counties that provides travel between WYO 59 at Wright and U.S. Route 16 (US 16) at Newcastle.

[1][2] Highway 450 heads due east through Thunder Basin National Grassland for much of its length.

Nearing 21 miles, WYO 450 leaves Campbell County and enters Weston.

The southern terminus of Wyoming Highway 116 is intersected at approximately 36.5 miles (58.7 km).

[1] Nearing its eastern end WYO 450 reaches the City of Newcastle, the county seat of Weston County, where it ends at US Route 16.