Highway 116 heads north through central Weston County, and turns northeast to Upton.

WYO 116 enters Upton from the southwest, and intersects U.S. Route 16 (2nd Street) at approximately 32.5 miles (52.3 km).

Highway 116 turns northwest and overlaps US 16 for a short distance through Upton, before leaving US 16 for its own routing, along Ash Street, toward Sundance.

[2] Route 116 continues to travel northerly, but as it nears the Crook County line, turns east and runs roughly parallel to it before turning north and crossing into Crook County.

The connection would be a short routing along US 87E between Ranchester and Sheridan (Modern-day US 14 between Greybull and Burgess Junction was then known as WYO 416).