The Xié River (Portuguese: Rio Xié) is a river of Amazonas state in north-western Brazil.

It is a right tributary of the Rio Negro.

The river flows through the 7,999,000-hectare (19,770,000-acre) Alto Rio Negro Indigenous Territory, created in 1998.

[1] The majority of the population of the Xié River are Baré and Werekena people.

[2] This article related to a river in the Brazilian state of Amazonas is a stub.