[4] This gene product belongs to the 14-3-3 family of proteins that mediate signal transduction by binding to phosphoserine-containing proteins.

This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs.

This gene is upregulated in patients with amyotrophic lateral sclerosis.

It contains in its 5' UTR a 6 bp tandem repeat sequence that is polymorphic; however, there is no correlation between the repeat number and the disease.

[5] YWHAQ has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.