520818640ENSG00000123836ENSMUSG00000026409O60825P70265NM_001018053NM_006212NM_001162415NM_001162416NM_008825NM_001368843NP_001018063NP_006203NP_001155887NP_001155888NP_032851NP_0013557726-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene.

[5] The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes.

This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle.

Two transcript variants encoding two different isoforms have been found for this gene.

[6] This article on a gene on human chromosome 1 is a stub.