The original station was built in the village of Yarmouth Port when the Cape Cod Railroad extended its line from Sandwich to Hyannis in 1854.

[1] In December 1865, the Cape Cod Central Railroad opened a branch from Yarmouth to Orleans, which was later extended to Provincetown.

[3][2] Service past Yarmouth to Provincetown ended with the 88 stations case on July 17, 1938, with a brief revival in mid-1940.

[2] Yarmouth station was again destroyed by fire in 1941; the New York, New Haven, and Hartford Railroad built a brick replacement.

[2] This station was torn down around 1975 to make room for the warehouse of Yarmouth-based Christmas Tree Shops.