American rock band Vanilla Fudge released a cover version in June the following year, which reached number six on the Billboard Hot 100.

In 1996, a version recorded by American country singer Reba McEntire reached number two on the US Billboard Hot Dance Club Play chart.

In the first 32 years of the Billboard Hot 100 rock era, "You Keep Me Hangin' On" became one of the six songs to reach number one by two different musical acts, for the Supremes and Wilde versions.

The song's signature guitar part is said to have originated from a Morse code-like radio sound effect, typically used before a news announcement, heard by Lamont Dozier.

[6] Many elements of the recording, including the guitars, the drums, and Diana Ross's vocals were multitracked, a production technique which was established and popularized concurrently by Holland–Dozier–Holland (H–D–H) and other premier producers of the 1960s such as Phil Spector (see Wall of Sound) and George Martin.

"[11] Cash Box said that it is "another in [the Supremes'] long-line of strong 'Detroit' offerings" that "is bound to follow in footsteps of the group’s previous winners.

[15] Vanilla Fudge's 1967 psychedelic rock remake titled "You Keep Me Hanging On" reached number six on the Billboard Hot 100 chart a year after the release of the Supremes' recording.

If you lived through that situation, the lyrics are definitely not happy.The Vanilla Fudge version appears in the series finale of the television show The Sopranos (2007), at the conclusion of episode 1 of season 7 of the television series Mad Men (2015),[43] the film War Dogs (2016), the video game Mafia III (2016), the film Once Upon a Time in Hollywood (2019) and its soundtrack, and over the closing credits of the "Intervention" (2022) episode of That Damn Michael Che.

[58] It also became Wilde's second and last top-40 entry in the United States following "Kids in America" (1981), as well as her most successful song in that country to date, reaching number one on the Billboard Hot 100 chart for one week in June 1987.

France Gold + 250.000 American country singer Reba McEntire covered "You Keep Me Hangin' On" in 1995 for her twenty-second studio album, Starting Over (1996).

Playfully digging into the Supremes' pop classic, McEntire has a saucy style that is well-suited to the track's storm of bright pop/house percussion and sugary synths.

Her country base may find this a tad hard to swallow, but it is so darn good that you'll be wishing for another romp in the disco round ASAP.

According to The New York Times, it "transforms the tune from an urban teen-oriented lament into a mountain-flavored folk song of quiet, adult desperation.