Located in the Palacio de la Música and formerly in the José Peón Contreras theater, the orchestra performs 2-3 subscription concerts every month in addition to special community events in the Mérida area.

Its previous guest conductors have included Maciej Żółtowski, Grigor Palikarov, and Michele Santorsola, and it has performed with soloists such as Jorge Federico Osorio, Carlos Prieto, Alexei Volodin, Stephanie Chase, and Leticia Moreno.

The efforts of his replacement, the music student Amilcar Cetina Gutiérrez, to continue and expand upon Pachón's orchestra ultimately failed due to the fall of Felipe Carillo Puerto's government after the assassination of Venustiano Carranza.

In 1936, violinist and ethnomusicologist Samuel Martí, who initially traveled to Mérida to study the music of the indigenous Maya people, began an orchestra jointly conducted by himself and Rejón that lasted for two years and performed six concerts in total.

[1][2] Between 1987 and 2002, the Autonomous University of Yucatan collaborated with the Institute of Culture to perform a dozen orchestral concerts led by Miguel Pérez Concha in locations including Mérida, Miami, Florida, and Chichen-Itza.

[1][2] The fund for the support of the OSY was founded in February 2001 in Mérida by the Institute of Culture with Domingo Rodriguez, Mari Eli Sosa, and Leroy Osmon as organizers under the direction of the governor.