[8] ZNF703 directly accumulates histone deacetylases at gene promoter regions but does not bind to functional DNA.

[8] Researchers attempted to discern factors associated with various cancer types through observation of the oncogenic mechanism on a molecular scale.

[8] The luminal B cancer pathway exhibited an amplification of 5 different genomic areas including the chromosome region 8p12.

[13] The ZNF703 gene generally plays an active role in luminal B tumor cells contained in mammary ducts.

[5] ZNF703 overexpression also causes primary and secondary tumorsphere development alongside amplified production of CD49F- positive cells associated with colon cancer.

[14] Researchers recently established a link between the trigger gene ZNF703 and Akt/mTOR pathway activation involved in the cellular cycle resulting in lung tumor formation.

[12] Tamoxifen can only be given at low dosages and patients are monitored daily in order to avoid tumor growth.