Zapotiltic is a town and municipality in the south region of the state of Jalisco, Mexico.

The name Zapotiltic comes from the Náhuatl words Tzápotl ('zapote') and tlíitic ('black'), meaning 'place of the black zapotes'.

The incumbent municipal president is Jorge Silva, a member of the Hagamos political party .

In 1936, the Municipal Palace was taken amidst shootings, blood, and fire, by command of the State Government; since the outgoing municipal president, Cayetano Vega, refused to hand over power.

[3] The municipality has 38 towns, the most important are: Zapotiltic (municipal seat), Arco de Cobianes (El Coahuayote), El Rincón, Tasinaxtla (La Cañada), Aserradero, Huescalapa, Villa Lázaro Cárdenas (Aserradero).