During her lifetime she worked as an electronics engineer, fashion designer, drafter, technical writer, and supervisor of government projects.

According to her own account her interest in native Indian cultural heritage and history was sparked by her grandfather, who used to tell her about tribal traditions and rituals during her childhood.

She took up residence after completing her course and, working as a draftsperson, fashion designer, technical writer and supervisor of government projects.

She also co-owned a textile printing company during her stay in Washington D.C.[10] Brough served as a civilian consultant to the United States Army Air Forces during World War II.

After her arrival, Brough accepted the job of vice president of the former Ibis Corporation located in Waltham, Massachusetts, which specialized in electronic and environmental consultation.

In 1962 she founded the Hassanamisco Museum which was nicknamed "Memorial to the Eastern American Indian" to document and preserve Nipmuc heritage.

The Hassanamisco Museum contains displays of artifacts, manuscripts, crafts, tribally specific legends, and news clippings pertaining to many Native American ethnic groups.

[18][7] In addition to her involvement with numerous committees she chaired the board of directors of the Hassanamisco Reservation Foundation Trust, which works to promote and ensure preservation of Nipmuc tribal lands and heritage.

In her capacity as an electronics engineer, worked in collaboration with Vance Parker and Brent Haslam and published research detailing theoretical applications of "Pattern Ratio Technique" to arrays.

Her most concerted effort was a petition for Nipmucs to be granted the status of one of the Federally recognized tribes of the Native American peoples.