Zaza belonged to the old aristocratic family Panaskerteli, originally owners of the frontier region of Panaskerti.
After an important role in the royal administration and in the army, Zaza retreated to a chapel he had built near Kintsvisi Monastery in which his mural depiction has survived.
Zaza's Karabadini (ultimately from the Greek graphidion, “booklet”) is an original medical treatise dated to c. 1486.
It builds upon anonymous Georgian compendia of Galenic medicine, notably the 11th-century Ustsoro Karabadini (Peerless Handbook) and the 13th-century Tsigni Saakimoy (Doctoring Book).
The work summarizes the state of medical knowledge in Georgia and neighboring cultures at that time.