Zegelsem is a village in the municipality of Brakel in the province of East Flanders, Belgium.

The village was first mentioned in 866 as "Sigulfi villa", and means "settlement of Sigiwulf (person)".

The parish church which was later built, was dedicated to Ursmar, the first abbot of the Lobbes Abbey.

As a result, it is featured in road cycling races like the Tour of Flanders.

The church has an organ built in 1753 by Lambert Van Peteghem, and a rood screen in Louis XIV style.