In the life of Saint Trudo, the founder of the nearby city of Sint-Truiden, is noted how the holy boy held a regularly nocturnal pilgrimage to Saint-Genevieve of Paris, especially worshipped in Zepperen.

Till the end of the 18th century the village was an enclave owned by the chapter of Saint-Servaas of Maastricht amidst the land of the principality of Liège.

The popular pilgrimage to the so-called ‘Three holy sisters” stimulated this chapter to build a beautiful church in Zepperen.

The famous Sint-Aloysius institute originated in the buildings of the former supreme convent of the Begards in the diocese of Liège, founded on the banks of the Melsterbeek in Zepperen in 1425.

In the interval of the 19th and early 20th century these buildings were transformed in a castle for the noblemen of the families de Pitteurs, d’Astier and Loyaerts.

In the second World war there were two crashes in Zepperen: on the 30 July 1942 a German Junker 88-A4 was destroyed on landing, the three occupants died.

Two members of the resistance were shot dead near a crossroad “De Dikke Linde” by collaborationists of the German occupation force.