[5] When it was originally released for the Amiga, Zool 2 received positive reception from critics who praised the graphics, sound department and gameplay, with some considering it as an improvement over the first game.

As with the original game, the sequel features several minigames, such as a version of Breakout which involves using Zoon, the two-headed morphing pet dog of Zool and Zooz, as a paddle in order to keep the ball in play by bouncing it upwards.

[7] Krool, the main antagonist of the original game has sent his forces and Mental Block, his shapeshifting henchman to invade the Nth dimension and seize power in order to stifle the imagination of the world, causing rampant boredom in the process.

Zool, the main protagonist of the first game, alongside his companion Zooz and their two-headed mascot Zoon, are entrusted with the mission of restoring order to the dimension and defeat Mental Block.

[7] After traversing through multiple locations, the trio reaches the main area where Mental Block resides and they defeat him, saving the dimension as a result, with a hint at a possible further sequel.

[24] Mike Weigand of Electronic Gaming Monthly assessed it as "a pretty good version of the pint-sized ninja character", particularly noting the large levels, though he felt the graphics were sometimes "visual overkill".