It flows in a south-westerly direction through the talukas of Tiswadi, Ponda, Mormugao, Salcete, Sanguem and Quepem.

The Cumbarjua Canal, linking the two rivers has enabled ships navigate to the interior regions to the iron ore mines.

The waters of the Mandovi and Zuari both flush out into the Arabian Sea at Cabo Aguada, a common point forming the Mormugao harbour.

The port city of Vasco da Gama, Goa lies on the mouth of the Zuari River.

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