Ōkubo Tadayoshi (大久保 忠良, May 27, 1857 – March 29, 1877) was the 10th and final daimyō of Odawara Domain in Sagami Province, (modern-day Kanagawa Prefecture) in Bakumatsu period Japan.

Before the Meiji Restoration, his courtesy title was Kaga no Kami.

Tadayoshi was appointed domain governor on June 22, 1868, holding that post to the abolition of the han system in 1871.

However, in 1877, Tadayoshi participated in the Satsuma Rebellion, and was killed in combat in Kumamoto Prefecture on March 29, 1877.

His grave is at the clan temple of Saisho-ji in Setagaya, Tokyo.