Following the defeat of the Later Hōjō clan in the Battle of Odawara by the forces of Toyotomi Hideyoshi in 1590, their vast territories in the Kantō region were assigned to Tokugawa Ieyasu.
Ieyasu selected Edo to be the headquarters of his new domains, and assigned his close retainer, Ōkubo Tadayo to rebuild Odawara Castle and to rule as a daimyō over the strategically important post town, which guarded the approaches to Edo from the west via the Hakone Pass.
Ōkubo Tadayo's territory included 147 villages in Ashigarakami and Ashigarashimo districts with total revenues of 40,000 koku.
His son Tadachika served in the Tokugawa shogunate as a rōjū and had his revenues increased by 20,000 koku with additional territories in Musashi Province.
During the Bakumatsu period, the shogunate relied on troops from Odawara to maintain a guard on the increasing foreign presence in Izu Peninsula, particularly Shimoda and Heda.