4126110173ENSG00000109323ENSMUSG00000028164O00462Q8K2I4NM_005908NM_027288NP_005899NP_081564β-Mannosidase (EC 3.2.1.25}, mannanase, mannase, β-D-mannosidase, β-mannoside mannohydrolase, exo-β-D-mannanase, lysosomal β A mannosidase) is an enzyme with systematic name β-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene.

[5][6][7][8][9][10] This enzyme catalyses the following chemical reaction This gene encodes a member of the glycosyl hydrolase 2 family.

The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism.

Mutations in this gene are associated with β-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.

This article on a gene on human chromosome 4 is a stub.