[1] The 107th Illinois left Camp Butler on September 30, 1862, and arrived at Jeffersonville, Indiana, where the officers were admonished that the men were a poorly-trained lot.

On October 18 the regiment was ordered to Elizabethtown, Kentucky (near the birthplace of President Abraham Lincoln) to repel a raid by Confederate cavalry under John Hunt Morgan.

The regiment spent much of the summer of 1863 trying to chase down John Hunt Morgan and his band of Confederate raiders and participated in the capture of approximately 700 Rebels at Buffington Island, Ohio.

On November 18 their division, commanded by Brigadier General Thomas Ruger advanced to Columbia, Tennessee, to meet Hood's army.

The following day the army was in a defensive position surrounding Franklin, with Schofield hoping to delay Hood long enough for Union strength to be concentrated at Nashville.

During the Battle of Franklin the regiment was near the apex of the Confederate assault and suffered heavy casualties, including the mortal wounding of their commander, Colonel Francis H. Lowrey.

After the surrender of Johnston's Confederate forces on April 26, the regiment remained on occupation duty in Salisbury, North Carolina, until June 21, 1865, when they were mustered-out.