109 Street is an arterial road in central Edmonton, Alberta, Canada.

It takes travelers out of Downtown to the south to Old Strathcona, and to the north to the Kingsway area.

It passes several Edmonton landmarks including the Garneau Theatre, Alberta Legislature Building, MacEwan University, RCMP "K" Division Headquarters, and Kingsway Mall.

It is a one-way street, southbound, from 97 Avenue to Saskatchewan Drive (88 Avenue), to cross the North Saskatchewan River on the narrow High Level Bridge.

On October 12, 2020, a 23 meter deep sinkhole opened up on the intersection of 61 Avenue and 109 St. [5]