The unit surrendered with General Joseph E. Johnston and the Army of Tennessee at Bennett Place on April 26, 1865.

Colonel Manigault, a veteran of the Mexican–American War, had trained, drilled and shaped his 12 companies with the assistance of the cadets from The Citadel, The Military College of South Carolina; and the regiment soon gained a reputation for its disciplined appearance.

The regiment moved to the coast and was stationed at Cat Island Redoubt, located between Winyah Bay and Santee River; and went into garrison and winter quarters.

In April and May it participated in the Siege of Corinth and was used on picket and fatigue duty until the army retreated to Tupelo, Mississippi.

Recuperating and reorganizing in Tupelo Col. Manigault commenced his drill and fostered his regiment's reputation.

Gen. Sheridan's Division (brigaded of Sill, Schaefer and Roberts) as left of McCook's wing.

With support from the neighboring Tennessee brigade the counterattacks were stopped, and in the following advance around 9 a.m. the Carolina regiments captured two 6-pounders from Bush's battery when Sheridan's division was completely driven back.

Manigault's brigade stayed in reserve on this position for the rest of the battle [6][3] The 10th South Carolina lost 16 dead, 91 wounded and 2 missed, making 109 total casualties.

In January 1863, as result of the high losses taken during the campaigns, the 10th was consolidated with the 19th South Carolina Infantry.

During the summer the consolidated 10th-19th South Carolina Infantry participated in the Tullahoma Campaign and the Middle Tennessee Operations.

[8] Spending the August with marches on September 18 Manigault's brigade, a part of Hindman's division in Polk's corps, was positioned at the left of the Confederate lines near Chickamauga guarding the river crossing near the Lee & Gordon's Mill.

A general assault by the whole army on the morning of the 20th was planned, and the brigade formed the left of the division, now commanded by Gen. J. Patton Anderson.

It was now the extreme left of the assault column; and faced elements of the Union XX Corps.

Sheridan's two remaining brigades finally checked the Confederate advance west of the Dyer field near the Widow Glenn House.

Armed with Spencer repeating rifles it drove Manigault's brigade around and through what became known as "Bloody Pond".

Facing Gordon Granger's Reserve Corps, supported by artillery Hindman's and Johnson's divisions tried to break the Union's lines, but the federals, partially armed with Colt revolving rifles, repulsed the assaulting Confederates.