The 1940–41 season was the 19th edition of the amateur league called Liga Mayor.
It had 8 participating clubs, after Moctezuma de Orizaba and Selección Jalisco joined the league.
[1] Selección Jalisco, Atlante FC and Club América awarded their matches against Asturias FC played on 15, 22 and 29 December 1940 by undue alignment of Asturias' player René Hansen.