The 1997–98 Prairie View A&M Panthers basketball team represented Prairie View A&M University during the 1997–98 NCAA Division I men's basketball season.

The Panthers, led by 13th-year head coach Elwood Plummer, played their home games at the William Nicks Building in Prairie View, Texas as members of the Southwestern Athletic Conference.

In the SWAC Tournament, they defeated Jackson State, Alabama State, and Texas Southern to win the SWAC championship.

The Panthers received an automatic bid to the NCAA tournament – the first appearance in program history – as the 16 seed in the Midwest region.

1 seed Kansas in the opening round[1] to finish the season with a 13–17 record.