The 2019–20 Prairie View A&M Panthers basketball team represented Prairie View A&M University in the 2019–20 NCAA Division I men's basketball season.

The Panthers, led by fourth-year head coach Byron Smith, played their home games at the William Nicks Building in Prairie View, Texas as members of the Southwestern Athletic Conference.

They defeated Alabama A&M in the quarterfinals of the SWAC tournament and were set to take on Jackson State in the semifinal before the tournament was cancelled amid the COVID-19 pandemic.

In the SWAC tournament, they defeated Alcorn State in the quarterfinals,[1] Grambling State in the semifinals[2] advancing to the championship game, where they defeated Texas Southern, earning the SWAC's automatic bid into the NCAA tournament.

[3] In the NCAA Tournament, they were matched up against Fairleigh Dickinson in the First Four, resulting in a 76–82 loss for the Panthers.