The 2021–22 Prairie View A&M Panthers basketball team represented Prairie View A&M University in the 2021–22 NCAA Division I men's basketball season.

The Panthers, led by sixth-year head coach Byron Smith, played their home games at the William Nicks Building in Prairie View, Texas as members of the Southwestern Athletic Conference.

In a season limited due to the ongoing COVID-19 pandemic, the Panthers finished the 2020–21 season 16–5, 13–0 in SWAC play to finish as the regular season co-champions, alongside Jackson State.

In the SWAC tournament, they defeated Mississippi Valley State[1] and Grambling State[2] before being upset in the championship game by Texas Southern.

[3] Roster Last update: October 30, 2021 Source[4]