The 2016–17 Prairie View A&M Panthers basketball team represented Prairie View A&M University during the 2016–17 NCAA Division I men's basketball season.

The Panthers, led by first-year head coach Byron Smith, played their home games at the William Nicks Building in Prairie View, Texas as members of the Southwestern Athletic Conference.

4 seed in the SWAC tournament, they lost to Grambling State in the quarterfinals.

They lost in the quarterfinals of the SWAC tournament to Jackson State.

On January 27, 2016, following a 1–16 start to the season, head coach Byron Rimm II resigned.