The 1999–2000 Alpha Ethniki was the 64th season of the highest football league of Greece.
The season began on 19 September 1999 and ended on 28 May 2000.
Olympiacos won their fourth consecutive and 29th Greek title.
AEK Athens qualified through the Cup, the 3rd league UEFA Cup place is decided between the teams within 5 points from 6th to 8th place.
UEFA Cup Play-off Iraklis with two Home-matches, Aris one, Panionios none