The chemical compound 1L-chiro-inositol[2] (often called L-chiro-inositol or LCI) is one of the nine stereoisomers of cyclohexane-1,2,3,4,5,6-hexol, with formula C6H12O6, the generic "inositol".

Imagining the ring is horizontal, the hydroxyls on carbons 1, 2, and 4, in clockwise order are above the respective hydrogens, while the other three are below them.

[4] It can be prepared also from para-benzoquinone by enzymatic action on a derived conduritol B intermediate;[5] or by controlled oxidation of cyclohexa-3,5-diene-1,2-diol.

[6][7] Another viable method is decomposition of plant-sourced quebrachitol, which can be obtained in good quantity from natural rubber serum (NRS), the liquid remaining from coagulation of latex from Hevea brasiliensis.

[9] [8] L-chiro-inositol can be extracted from dead leaf material from the seagrass Syringodium filiforme that washes up as flotsam on Caribbean beaches.