1WOJ126712799ENSG00000173786ENSMUSG00000006782P09543P16330NM_033133NM_001330216NM_001146318NM_009923NP_001317145NP_149124NP_001139790NP_0340532′,3′-Cyclic-nucleotide 3'-phosphodiesterase (EC 3.1.4.37, CNPase, systematic name nucleoside-2′,3′-cyclic-phosphate 2′-nucleotidohydrolase) is an enzyme that in humans is encoded by the CNP gene.
[7] It is named for its ability to catalyze the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides, though a cohesive understanding of its specific physiologic functions are still ambiguous.
[8] Structural studies have revealed that four classes of CNPases belong to one protein superfamily.
Deletion of the C-terminus of CNPase or phosphorylation abolish the catalytic activity of microtubule formation.
CNPase can link tubulin to cellular membranes, and might be involved in the regulation cytoplasmic microtubule distribution.