2,4,6-Trimethylpyridine (2,4,6-collidine) is an organic compound which belongs to the heterocycles (more precisely, heteroaromatics).

It consists of a pyridine ring substituted with three methyl groups.

[4][5] A synthesis can be carried out analogously to the Hantzsch's dihydropyridine synthesis from ethyl acetoacetate (as β-ketocarbonyl compound), acetaldehyde and ammonia in the ratio 2: 1: 1.

[6] By oxidation of the methyl groups with potassium permanganate collidinic acid is obtained.

[7] 2,4,6-Trimethylpyridine is used in organic syntheses (for example, for dehydrohalogenation[8]), by binding the formed hydrogen halides.