2,6-Xylenol is a chemical compound which is one of the six isomers of xylenol.

The methylation is carried out by contacting gaseous phenol and methanol at elevated temperatures in the presence of a solid acid catalyst:[2][3] Challenges associated with the production is the similarity of the boiling points of cresols and this xylenol.

2,6-Xylenol is susceptible to oxidative coupling leading to polymers and dimers.

[4] Acid-catalyzed condensation of 2,6-xylenol gives tetramethylbisphenol A.

2,6-Xylenol reacts with ammonia to give 2,6-dimethylaniline.