The systematic name of this enzyme class is acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming).
This enzyme participates in biosynthesis of L-leucine and pyruvate metabolism.
Monovalent and divalent cation activation have been reported for enzymes from different sources.
Another feature of the M. tuberculosis homolog is that L-leucine, the feedback inhibitor, inhibits the enzyme in a time-dependent fashion.
[6] As of late 2007, only one tertiary structure has been solved for this class of enzymes, with the Protein Data Bank accession code 1SR9.