[8][9][10][7] In animal studies, 20α-DHP has been found to be selectively taken up into and retained in target tissues such as the uterus, brain, and skeletal muscle.

[1][2][3][11][12][6][13] It has also been found to act as an aromatase inhibitor and to inhibit the production of estrogen in breast tissue in vitro.

[14] A single 200-mg oral dose of micronized progesterone has been found to result in peak levels of 20α-DHP of around 1 ng/mL after 2 hours.

[15] In another study however, peak levels of 20α-DHP were around 10 ng/mL during therapy with 300 mg/day oral micronized progesterone.

[16] 20α-DHP is formed from progesterone in the liver and in target tissues such as the endometrium.