The 2000–01 Southwest Missouri State Lady Bears basketball team represented Southwest Missouri State University during the 2000–01 NCAA Division I women's basketball season.
The Lady Bears, led by 14th-year head coach Cheryl Burnett, played their home games at Hammons Student Center and were members of the Missouri Valley Conference.
They received an automatic bid to the NCAA tournament and were assigned the No.
6 seed Washington to reach the second Final Four in program history[2].
[3] Southwest Missouri State spent the entire season ranked in both major polls.