The 2020–21 Missouri State Lady Bears basketball team represented Missouri State University during the 2020–21 NCAA Division I women's basketball season.

The Lady Bears, led by second year head coach Amaka Agugua-Hamilton, played their home games at JQH Arena and were members of the Missouri Valley Conference.

They finished the season 23–3 and 16–0 in conference play to finish as Missouri Valley Conference champions.

As the first seed in the Missouri Valley tournament, they defeated Southern Illinois in the quarterfinals before having to forfeit their semifinal game.

[1] They received an at-large bid to the NCAA tournament and were the fifth seed in the Alamo Regional.